Golgicide A
Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1[1]. Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species[2].
Product Specifications
CAS Number
1139889-93-2
Product Name Alternative
GCA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Enterovirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/golgicide-a.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC2=C(NC(C3=CC=CN=C3)[C@@]4([H])[C@]2([H])C=CC4)C(F)=C1
Molecular Formula
C17H14F2N2
Molecular Weight
284.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Sáenz JB, et al. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nat Chem Biol. 2009 Mar;5 (3) :157-65.|[2]van der Linden L, et al. Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication. J Virol. 2010 Aug;84 (15) :7535-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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