Golgicide A

Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1[1]. Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species[2].

Product Specifications

CAS Number

[1139889-93-2]

Product Name Alternative

GCA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Enterovirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/golgicide-a.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC2=C(NC(C3=CC=CN=C3)[C@@]4([H])[C@]2([H])C=CC4)C(F)=C1

Molecular Formula

C17H14F2N2

Molecular Weight

284.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Sáenz JB, et al. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nat Chem Biol. 2009 Mar;5 (3) :157-65.|[2]van der Linden L, et al. Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication. J Virol. 2010 Aug;84 (15) :7535-42.