KI-ARv-03
KI-ARv-03 is a potent and selective ATP-competitive CDK9 inhibitor with an IC50 of 0.15 μM (in the presence of 45 μM ATP), demonstrating over 130-fold selectivity for CDK9 over other CDKs (including CDK1-7) . It reduces AR-driven transcription and proliferation in prostate cancer cells and is applicable for research on leukemia, pancreatic cancer, alveolar rhabdomyosarcoma (ARMS), and castration-resistant prostate cancer (CRPC) . Additionally, KI-ARv-03 serves as a ligand for target protein for PROTAC and is used in the synthesis of PROTAC KI-CDK9d-32.
Product Specifications
CAS Number
2416873-72-6
Smiles
N (C=1N2C (N=C (CCC) C1) =CC=N2) [C@H]3C[C@H] (N) CC3
Molecular Formula
C14H21N5
Molecular Weight
259.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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