PROTAC ERα Degrader-13

PROTACERαDegrader-13 is an orally bioavailable, highly potent, and selective PROTAC molecule designed to degrade ERα with a DC50 of 3.78 nM. It demonstrates strong antiproliferative activity (IC50 = 0.6 nM) in MCF-7 cells and exhibits characteristics such as inducing apoptosis and overcoming drug resistance. PROTACERαDegrader-13 has been shown to have a good safety profile without notable organ toxicity, making it suitable for cancer research.