ALK degrader 1

ALK degrader 1 is a potent degrader using hydrophobic tagging technology (HyT), relying on the ubiquitin-proteasome system to degrade EML4-ALK with a DC50 of 0.13 μM. It demonstrates superior ALK degradation and antiproliferative effects in ALK-dependent cell lines, with no significant cytotoxicity in ALK fusion-negative cells. The compound induces G0/G1 cell cycle arrest and promotes apoptosis, efficiently degrades ALK proteins, and blocks key downstream signaling pathways such as STAT3. Additionally, ALK degrader 1 effectively induces EML4-ALK degradation in vivo and is suitable for researching ALK-related diseases.