IKZF2-degrader 2

IKZF2-degrader 2 is a selective, orally active molecular glue degrader for IKZF2, with DC50 values of 0.5 nM (HiBit) and 1.8 nM (FACS) . It facilitates ubiquitination and degradation of target proteins by recruiting the CRL4-CRBN E3 ubiquitin ligase. IKZF2-degrader 2 shows moderate degradation activity against SALL4 (DC50 of 9 nM) but does not significantly degrade IKZF1, IKZF3, CK1α, or GSPT1. This compound is suitable for research in cancer immunology.