DGY-09-192
DGY-09-192 is a PROTAC FGFR1/2 degrader with DC50 values of 4.35 nM for FGFR1 and 70 nM for FGFR2. It selectively degrades wild-type FGFR1/2 and various FGFR2 fusion proteins, including FGFR2-PHGDH and FGFR2-OPTN. In both in vitro and in vivo studies, DGY-09-192 inhibits downstream FGFR signaling pathways by reducing the phosphorylation of FRS2Y196 and ERK1/2T202/Y204.
Product Specifications
CAS Number
2504949-52-2
Smiles
C ([C@@H] (NC (CN1CCN (CC1) C2=CC=C (NC=3C=C (N (C (NC4=C (Cl) C (OC) =CC (OC) =C4Cl) =O) C) N=CN3) C=C2) =O) [C@@] (C) (C) C) (=O) N5[C@H] (C (N[C@@H] (C) C6=CC=C (C=C6) C7=C (C) N=CS7) =O) C[C@@H] (O) C5
Molecular Formula
C49H59Cl2N11O7S
Molecular Weight
1017.04
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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