PROTAC OSBP Degrader-1

PROTACOSBP Degrader-1 (Compound 5) is a PROTAC degrader of oxysterol-binding protein (OSBP) with a DC50 of 322 nM at 24 hours. It efficiently penetrates cells and induces significant recruitment of OSBP at the trans-Golgi network. This compound exhibits potent anticancer activity and demonstrates strong cytotoxicity against U-87 MG, A549, MCF7, HeLa, and MDA-MB-231 cells.