SD-6
SD-6 is an orally active inhibitor of hAChE and hBChE with IC50 values of 0.907 µM and 1.579 µM, respectively. SD-6 has excellent blood-brain barrier (BBB) permeability and no neurotoxicity, which can be used for research on Alzheimer's disease[1].
Product Specifications
CAS Number
[744206-31-3]
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sd-6.html
Concentration
10mM
Purity
98.0
Solubility
10 mM in DMSO
Smiles
S=C1OC(C2=CC=CC=C2)=NN1CN3CCN(CC3)CC4=CC=CC=C4
Molecular Formula
C20H22N4OS
Molecular Weight
366.48
References & Citations
[1]Waiker DK, et al. Development and Evaluation of Some Molecular Hybrids of N- (1-Benzylpiperidin-4-yl) -2- ((5-phenyl-1,3,4-oxadiazol-2-yl) thio) as Multifunctional Agents to Combat Alzheimer's Disease. ACS Omega. 2023 Mar 2;8 (10) :9394-9414.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
Available Sizes
Curated Selection
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