SD-6

SD-6 is an orally active inhibitor of hAChE and hBChE with IC50 values of 0.907 µM and 1.579 µM, respectively. SD-6 has excellent blood-brain barrier (BBB) permeability and no neurotoxicity, which can be used for research on Alzheimer's disease[1].

Product Specifications

CAS Number

[744206-31-3]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sd-6.html

Concentration

10mM

Purity

98.0

Solubility

10 mM in DMSO

Smiles

S=C1OC(C2=CC=CC=C2)=NN1CN3CCN(CC3)CC4=CC=CC=C4

Molecular Formula

C20H22N4OS

Molecular Weight

366.48

References & Citations

[1]Waiker DK, et al. Development and Evaluation of Some Molecular Hybrids of N- (1-Benzylpiperidin-4-yl) -2- ((5-phenyl-1,3,4-oxadiazol-2-yl) thio) as Multifunctional Agents to Combat Alzheimer's Disease. ACS Omega. 2023 Mar 2;8 (10) :9394-9414.