Idasanutlin (enantiomer)

Idasanutlin enantiomer is the isomer of Idasanutlin (HY-15676), and can be used as an experimental control. Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM.

Product Specifications

CAS Number

[9007-83-4]

Product Name Alternative

RG7388 (enantiomer)

UNSPSC

12352005

Target

Apoptosis; Drug Isomer; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/idasanutlin-enantiomer.html

Purity

99.18

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C([C@H]1N[C@H](CC(C)(C)C)[C@](C2=CC=C(Cl)C=C2F)(C#N)[C@@H]1C3=CC=CC(Cl)=C3F)NC4=C(OC)C=C(C(O)=O)C=C4

Molecular Formula

C31H29Cl2F2N3O4

Molecular Weight

616.48

References & Citations

[1]Ding Q, et al. Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development. J Med Chem. 2013 Jul 25;56 (14) :5979-83.|[2]Higgins B, et al. Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach. Clin Cancer Res. 2014, 20 (14), 3742-3752.