Aromatase-IN-8

Aromatase-IN-8 is a selective aromatase inhibitor with an IC50 of 0.05 μM for aromatase activity. It exhibits selective antiproliferative effects on estrogen receptor-positive breast cancer cell lines while being non-toxic to non-tumor cells. Aromatase-IN-8 suppresses estrogen activity, elevates testosterone levels, and downregulates estrogen receptor expression and phosphorylation. It is applicable for research in triple-negative breast cancer.