Dual GO/LDHA-IN-1

Dual GO/LDHA-IN-1 is an orally effective dual-target inhibitor of glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), with Ki values of 390 nM and 40 nM, respectively. It decreases liver LDHA levels, urinary oxalate excretion, and renal calcium oxalate crystal deposition. Dual GO/LDHA-IN-1 is applicable for research in primary hyperoxaluria type 1.