TSLP modulator-1

TSLP modulator-1 (Compound 14O) is a potent regulator of TSLP signaling. It effectively suppresses the expression of CCL17 and IL-1β mRNA and reduces the protein levels of IL-6, IL-4, and IL-13. Additionally, TSLP modulator-1 significantly inhibits calcium influx (calcium influx) and exhibits anti-inflammatory properties, effectively alleviating itchiness and symptoms similar to atopic dermatitis.