AD-9308
AD-9308 is a highly selective, orally active ALDH2 activator. By activating ALDH2, it enhances the clearance of 4-HNE and inhibits myocardial fibrosis, inflammation, and apoptosis. AD-9308 improves mitochondrial function, regulates sarcoplasmic/endoplasmic reticulum calcium transport, and modulates autophagy, thereby restoring intracellular homeostasis. It improves diastolic and systolic dysfunction in diabetic mice and reverses adverse ventricular remodeling. AD-9308 is useful for studying diabetic cardiomyopathy.
Product Specifications
CAS Number
1804942-56-0
Smiles
C (OC ([C@H] (C (C) C) N) =O) C1=C (N=CC=C1) C2=CC (C (NCC3=CC (F) =C (OC) C=C3) =O) =C (OCC (C) C) C=C2
Molecular Formula
C30H36FN3O5
Molecular Weight
537.63
Storage Conditions
-20°C
Notes
For research use only.
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