DYRK2-IN-2

DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2 with an IC50 of 40.3 nM. It exhibits significantly lower inhibitory activity against DYRK1A (IC50 = 1842 nM), DYRK1B (IC50 = 1335 nM), DYRK4 (IC50 = 1931 nM), DYRK3 (IC50 = 112 nM), and CLK proteins (IC50 = 540-6496 nM) . DYRK2-IN-2 hinders the phosphorylation of Tau protein at Thr212 and demonstrates moderate cytotoxicity in HT22 cells. This compound is suitable for cancer research.