FGFR-IN-24

FGFR-IN-24 (Compound 8r) is an inhibitor of FGFR with potent activity against FGFR1/2/3, exhibiting IC50 values of 10.0, 6.9, and 30.2 nM, respectively. It also demonstrates strong inhibitory effects on mutant forms FGFR1V561M, FGFR2V564F, and FGFR2N549K, with IC50 values of 6.8, 0.7, and 0.8 nM. FGFR-IN-24 induces apoptosis (Apoptosis) and effectively inhibits the phosphorylation of FGFR2 and its downstream signaling mediators (AKT and MAPK) . It shows promising anti-tumor efficacy in the RT112/84 bladder cancer xenograft model.