3-Ethoxy-5,6-dibromosalicylaldehyde

3-ethoxy-5,6-dibromosalicylaldehyde is a potent, non-competitive, selective IRE1 (including IRE1α) inhibitor with IC50 values of approximately 0.12 μM for hIRE1α-cyto and 6 μM for yeast Ire1. It suppresses XBP-1 splicing and induces apoptosis. This compound upregulates TXNIP mRNA expression levels while downregulating TXN expression. Furthermore, 3-ethoxy-5,6-dibromosalicylaldehyde exhibits anticancer activity against pancreatic cancer and significantly inhibits the replication of the chikungunya virus.