3-Ethoxy-5,6-dibromosalicylaldehyde
3-ethoxy-5,6-dibromosalicylaldehyde is a potent, non-competitive, selective IRE1 (including IRE1α) inhibitor with IC50 values of approximately 0.12 μM for hIRE1α-cyto and 6 μM for yeast Ire1. It suppresses XBP-1 splicing and induces apoptosis. This compound upregulates TXNIP mRNA expression levels while downregulating TXN expression. Furthermore, 3-ethoxy-5,6-dibromosalicylaldehyde exhibits anticancer activity against pancreatic cancer and significantly inhibits the replication of the chikungunya virus.
Product Specifications
CAS Number
20041-64-9
Smiles
O=CC=1C (Br) =C (Br) C=C (OCC) C1O
Molecular Formula
C9H8Br2O3
Molecular Weight
323.97
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
AM33396PU-N 50 µg
TGM1 mouse monoclonal antibody, clone 6.4_2G6, Purified
Sign In for Pricing
View Details 
MBS1097688-01 0.02 mg (E-Coli)
Recombinant Proteus mirabilis Chorismate--pyruvate lyase (ubiC)
Sign In for Pricing
View Details MBS1097688-02 0.1 mg (E-Coli)
Recombinant Proteus mirabilis Chorismate--pyruvate lyase (ubiC)
Sign In for Pricing
View Details MBS1097688-03 0.02 mg (Yeast)
Recombinant Proteus mirabilis Chorismate--pyruvate lyase (ubiC)
Sign In for Pricing
View Details MBS1097688-04 0.1 mg (Yeast)
Recombinant Proteus mirabilis Chorismate--pyruvate lyase (ubiC)
Sign In for Pricing
View Details MBS1097688-05 0.02 mg (Baculovirus)
Recombinant Proteus mirabilis Chorismate--pyruvate lyase (ubiC)
Sign In for Pricing
View Details