MANT-GppNHp

MANT-GppNHp is a competitive inhibitor of adenylyl cyclase (AC) and a fluorescently labeled GTP analog. It interacts with a hydrophobic pocket near the AC catalytic site through its MANT group, directly obstructing the binding of the substrate ATP. MANT-GppNHp can be utilized in studies of diseases such as cholera, which are associated with increased AC activity.