W-5 (hydrochloride)
W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC50 value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7[2].
Product Specifications
CAS Number
61714-25-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Calmodulin
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/w-5-hydrochloride.html
Purity
99.93
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=C2C=CC=CC2=CC=C1)(NCCCCCCN)=O.[H]Cl
Molecular Formula
C16H23ClN2O2S
Molecular Weight
342.88
Precautions
H315, H319, H335
References & Citations
[1]Suzuki S, et al. Enhancement of the cAMP-induced apolipoprotein-mediated cellular lipid release by calmodulin inhibitors W7 and W5 from RAW 264 mouse macrophage cell line cells. J Cardiovasc Pharmacol. 2000 Nov;36 (5) :609-16.|[2]Yokokura S, et al. Calmodulin antagonists induce cell cycle arrest and apoptosis in vitro and inhibit tumor growth in vivo in human multiple myeloma. BMC Cancer. 2014 Nov 26;14:882.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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