HK2-IN-3
HK2-IN-3 (compound 12) is a potent hexokinase 2 (HK2) inhibitor with an IC50 of 56.4 nM. It reduces glucose uptake and downregulates GLUT1/GLUT4 expression in oral squamous cell carcinoma (OSCC) . HK2-IN-3 induces mitophagy (mitophagy) and apoptosis (apoptosis) . In OSCC xenograft mouse models, HK2-IN-3 suppresses tumor growth and angiogenesis. It can be utilized in OSCC research.
Product Specifications
CAS Number
2679261-30-2
Smiles
O=C (NN=CC1=CC=C (O) C (O) =C1O) C2=NC=3C=CC=CC3S2
Molecular Formula
C15H11N3O4S
Molecular Weight
329.33
Storage Conditions
-20°C
Notes
For research use only.
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