HK2-IN-3

HK2-IN-3 (compound 12) is a potent hexokinase 2 (HK2) inhibitor with an IC50 of 56.4 nM. It reduces glucose uptake and downregulates GLUT1/GLUT4 expression in oral squamous cell carcinoma (OSCC) . HK2-IN-3 induces mitophagy (mitophagy) and apoptosis (apoptosis) . In OSCC xenograft mouse models, HK2-IN-3 suppresses tumor growth and angiogenesis. It can be utilized in OSCC research.