CZh226 hydrochloride
CZh226 hydrochloride is a potent and selective inhibitor of PAK4, with an IC50 of 18 nM and a selectivity of 346-fold over PAK1. The oral bioavailability of CZh226 hydrochloride is poor, necessitating the use of the prodrug PAK4-IN-1 to enhance absorption and metabolic stability. It is applicable in research on colorectal cancer and melanoma.
Product Specifications
CAS Number
2231440-94-9
Smiles
N (C=1C2=C (N=C (C (=O) N3C[C@@H] (C) NCC3) N1) C=CC (Cl) =C2) C=4C=C (NN4) C5CC5.Cl
Molecular Formula
C20H23Cl2N7O
Molecular Weight
448.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
