O-Desmethyl dacomitinib
O-Desmethyl dacomitinib (PF-05199265) is the primary circulating metabolite of Dacomitinib and acts as a pan-ErbB tyrosine kinase inhibitor, targeting epidermal growth factor receptors. The exposure level of O-Desmethyl dacomitinib is significantly lower than that of Dacomitinib, and its formation is highly dependent on CYP2D6 enzyme activity.
Product Specifications
CAS Number
2468202-15-3
Smiles
N (C=1C2=C (C=C (O) C (NC (/C=C/CN3CCCCC3) =O) =C2) N=CN1) C4=CC (Cl) =C (F) C=C4
Molecular Formula
C23H23ClFN5O2
Molecular Weight
455.92
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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