Aβ/tau aggregation-IN-4

Aβ/tau aggregation-IN-4 (Compound D21) is an inhibitor of Aβ/tau aggregation. It promotes the degradation of Aβ40/42 with IC50 values of 2.151 μM for Aβ40 and 3.622 μM for Aβ42. This compound selectively inhibits AChE with an IC50 of 5.56 μM and also inhibits MAO-A and MAO-B with IC50 values of 0.59 μM and 0.09 μM, respectively. Additionally, Aβ/tau aggregation-IN-4 reduces intracellular ROS levels and is used in Alzheimer's disease research.