YHV98-4

YHV98-4 is a selective Hv1 channel (Hv1 channel) inhibitor that can cross the blood-brain barrier. It specifically inhibits the Hv1 channel with a half-maximal inhibitory concentration of 1 μM without affecting other ion channels. YHV98-4 decreases the spread of p-tau, enhances ATP production, and promotes microglial mitophagy. By inhibiting the Hv1 channel and reducing ROS production, it alleviates inflammatory pain. Additionally, YHV98-4 enhances the transfer of mitochondria (mitochondria) from microglia to neurons, aiding in the delivery of functional mitochondria, thereby repairing neuronal damage and improving cognitive function. It mitigates inflammation and is applicable in Alzheimer’s disease research.