ALK/HDAC-IN-2

ALK/HDAC-IN-2 (Compound 19b) functions as an ALK/HDAC inhibitor, demonstrating IC50 values of 8 nM for ALK WT and 1.18 μM for total HDACs. It is effective against ALK mutants G1202R, F1174L, and L1196M, with IC50 values of 2.74, 9.23, and 34.28 nM, respectively. The compound shows potent and selective inhibition of HDAC1 (IC50= 0.24 μM), while exhibiting weak inhibition against HDAC7, HDAC6, and HDAC11 (IC50> 10 μM) . Additionally, ALK/HDAC-IN-2 has broad-spectrum antiproliferative effects on various cancer cell lines, inducing cell cycle arrest and apoptosis. This compound is applicable for neuroblastoma research.