SMU-C409

SMU-C409 is a TLR1/2 agonist with an EC50 of 65 nM in HEK-Blue hTLR2 cells. It activates the TLR1/2–MyD88–NF-κB pathway, inducing TNF-α/IL-1β secretion and strongly activating immune cells, resulting in antitumor immunomodulatory effects. Exhibiting low toxicity in vitro, SMU-C409 is useful for cancer immunology research.