BRD4 D1-IN-3

BRD4 D1-IN-3 (compound 39) is a potent and highly selective BRD4-D1 inhibitor, exhibiting cellular activity with an IC50 of 39 nM and a Ki of 2.4 nM, and demonstrating over 1700-fold selectivity against BRD2-D1. In LPS-mediated liver inflammation cell models, BRD4 D1-IN-3 reduces the expression of pro-inflammatory chemokines CXCL1 and CCL2. This compound is applicable in studies of liver inflammation.