Cx43 HC-IN-1

Cx43 HC-IN-1 (Compound D4) is a selective, orally active inhibitor of connexin hemichannels (Cx43 HC) . It effectively suppresses hemichannel activity mediated by Cx43/Cx45 in denervated skeletal muscle fibers, significantly enhancing neuronal reinnervation of muscle fibers. By inhibiting hemichannels in brain glial cells, Cx43 HC-IN-1 reduces neuroinflammation and neuronal hyperexcitability, alleviating seizures in mice. It is applicable for research on epilepsy and muscular disorders.