Lazertinib mesylate hydrate
Lazertinib (YH25448) mesylate hydrate is a potent, selective, orally available, and irreversible EGFR tyrosine kinase inhibitor capable of crossing the blood-brain barrier. It exhibits high selectivity toward activating EGFR mutations (EGFRm) and T790M-resistant mutations. Lazertinib mesylate hydrate effectively inhibits the phosphorylation of EGFR, AKT, and ERK, leading to the induction of apoptosis and suppression of tumor growth in mouse models of H1975-luc brain metastases xenografts. This compound is applicable in the study of non-small cell lung cancer.
Product Specifications
CAS Number
2411549-88-5
Smiles
O=C (C=C) NC1=CC (NC2=NC=CC (=N2) N3N=C (C=4C=CC=CC4) C (=C3) CN (C) C) =C (OC) C=C1N5CCOCC5.O=S (=O) (O) C.O
Molecular Formula
C31H40N8O7S
Molecular Weight
668.77
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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