GS-1291269
GS-1291269 is a potent neutral ketohexokinase (KHK) inhibitor, exhibiting IC50 values of 0.38 nM for KHK-C and 2.1 nM for KHK-A. In a rat fructose challenge model, GS-1291269 effectively reduces fructose-1-phosphate (F1P) levels in the liver and kidneys. It is applicable in the study of renal diseases and metabolic dysfunction-associated steatotic liver disease (MASLD) .
Product Specifications
CAS Number
2845278-33-1
Smiles
FC1 (F) C=2C (=C (N=C (N2) N3[C@@H] (C (F) (F) F) CC3) C4=CC=C (C=C4) C5 (N) CS (=O) (=O) C5) CC1
Molecular Formula
C20H19F5N4O2S
Molecular Weight
474.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1385824 Inquire
Recombinant Human Lethal (2) giant larvae protein homolog 2 (LLGL2) , partial
Sign In for Pricing
View Details 