GS-1291269
GS-1291269 is a potent neutral ketohexokinase (KHK) inhibitor, exhibiting IC50 values of 0.38 nM for KHK-C and 2.1 nM for KHK-A. In a rat fructose challenge model, GS-1291269 effectively reduces fructose-1-phosphate (F1P) levels in the liver and kidneys. It is applicable in the study of renal diseases and metabolic dysfunction-associated steatotic liver disease (MASLD) .
Product Specifications
CAS Number
2845278-33-1
Smiles
FC1 (F) C=2C (=C (N=C (N2) N3[C@@H] (C (F) (F) F) CC3) C4=CC=C (C=C4) C5 (N) CS (=O) (=O) C5) CC1
Molecular Formula
C20H19F5N4O2S
Molecular Weight
474.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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