Azithromycin-amide-C3-amide-quinoxaline

Azithromycin-amide-C3-amide-quinoxaline (Compound 5f) is a derivative of Azithromycin and serves as an antibacterial agent. It inhibits topoisoisomerase I with an IC50 of 120.7 μM. The compound binds to the Escherichia coli 70S ribosome with a Kd of 0.8 nM and suppresses bacterial translation with an IC50 of 0.7 μM. It shows antibacterial activity against Streptococcus pneumoniae ATCC 49619, Staphylococcus aureus ATCC 29213, and Enterococcus faecalis ATCC 29212, with MIC values of 0.06 μg/mL, 2 μg/mL, and 0.5 μg/mL, respectively. Additionally, this compound exhibits anticancer activity against prostate and colorectal cancer.