GW559090
GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a Kd value of 0.19 nM for α4β1. It effectively inhibits the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin, with IC50 values of 7.72 and 8.04 nM, respectively. Additionally, GW559090 suppresses the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) with an IC50 value of 23 nM. It also inhibits inflammatory infiltration in the eye, repairs the corneal barrier, and restores goblet cell function, making it useful for research into dry eye syndrome associated with Sjögren's syndrome.
Product Specifications
CAS Number
278598-52-0
Smiles
C ([C@H] (NC ([C@@H] (NC (COC1=C (C) C=CC=C1) =O) CC (C) C) =O) C (O) =O) C2=CC=C (OC (=O) N3CCC (C (N) =O) CC3) C=C2
Molecular Formula
C31H40N4O8
Molecular Weight
596.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Pnpla1 sgRNA CRISPR Lentivector (Rat) (Target 3)
IRAK4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
