RIPK1-IN-39
RIPK1-IN-39 (compound 2) is a potent and selective inhibitor of RIPK1 with an IC50 of 69.40 nM, exhibiting over 100-fold selectivity for RIPK1 over RIPK3 (IC50= 6946 nM) . It protects HT-22 and HT-29 cells from necroptosis by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL pathway. Additionally, RIPK1-IN-39 shows neuroprotective effects in a rat middle cerebral artery occlusion (MCAO) model. This compound is applicable in acute ischemic stroke (AIS) research.
Product Specifications
CAS Number
3065634-42-3
Smiles
C (N[C@@H] (C) C1=CC=C (F) C=C1) (=O) C=2C3=C (C=CC (=C3) C=4C=C5C (=CC4) N=C (NC (=O) C6CC6) S5) N=C (C) N2
Molecular Formula
C29H24FN5O2S
Molecular Weight
525.6
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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