HDAC/HSP90-IN-2

HDAC/HSP90-IN-2 (compound 26) is a potent dual inhibitor of HDAC (IC50= 194 nM) and HSP90 (HSP90α IC50= 153 nM) . It induces HSP70 expression, downregulates HSP90 substrate proteins, and promotes the acetylation of α-tubulin and histone H3 in cancer cells. Additionally, HDAC/HSP90-IN-2 reduces PD-L1 expression in H1975 cells treated with IFN-γ and is applicable in the research of cancers such as lung cancer and colon cancer.