TGR5 agonist 9
TGR5 agonist 9 is a highly selective, orally active allosteric agonist of TGR5, exhibiting EC50 values of 0.48 μM for hTGR5 and 0.49 μM for mTGR5. It recruits β-arrestin 1 (EC50= 78.8 μM) and β-arrestin 2 (EC50= 12.3 μM), and demonstrates enhanced efficacy in cAMP accumulation (EC50= 0.48 μM) . In ICR mouse models, TGR5 agonist 9 shows significant hypoglycemic effects, making it a potential candidate for diabetes research.
Product Specifications
CAS Number
2931879-67-1
Smiles
O (C) [C@H]1[C@]2 ([C@]3 ([C@@] (C) ([C@@] ([C@@H] (CCC (=O) N4CCCC4) C) (CC3) [H]) [C@@H] (O) C[C@@]2 ([C@]5 (C) [C@] (C1) (C[C@H] (O) CC5) [H]) [H]) [H]) [H]
Molecular Formula
C29H49NO4
Molecular Weight
475.71
Storage Conditions
-20°C
Notes
For research use only.
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