AChE-IN-105

AChE-IN-105 (Compound C5) is a potent mixed-type AChE inhibitor with an IC50 value of 5.02 μM. It effectively scavenges ROS, reduces hydrogen peroxide-induced Caspase-3 activation, and inhibits the Nrf2-ARE pathway. In a Scopolamine-induced zebrafish cognitive impairment model, AChE-IN-105 prevents memory deficits and demonstrates strong antioxidant activity. It is applicable in Alzheimer's disease research.