EGFR-IN-189
EGFR-IN-189 (Compound 7) is a selective covalent inhibitor of the epidermal growth factor receptor (EGFR) with an IC50 value of 200 nM. It effectively inhibits the C797S mutant form of EGFR, suppresses cancer cell proliferation, and inhibits phosphorylation of EGFR and downstream ERK1/2. EGFR-IN-189 is applicable in non-small cell lung cancer research.
Product Specifications
CAS Number
3037398-18-5
Smiles
O=C1C=C (C#C) C=2C=NC (=NC2N1C=3C=CC=CC3) NC4=CC=C (C=C4) N (C) CCN (C) C
Molecular Formula
C26H26N6O
Molecular Weight
438.54
Storage Conditions
-20°C
Notes
For research use only.
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