Multitarget AD-IN-5

Multitarget AD-IN-5 (Compound 20), a derivative of 9-Aminoacridine, is a neuroprotective agent. It exhibits IC50 values of 0.614 μM for hAChE, 0.448 μM for hBChE, 3.73 μM for MAO-A, and 1.55 μM for hMAO-B. This compound can reduce both the length and diameter of Aβ42 fibrils and decrease the number of fibrils per unit area. The CC50 value for SH-SY5Y cells is 95 μM. Multitarget AD-IN-5 is applicable in Alzheimer's disease research.