COX-1 ligand 1

COX-1ligand 1 (Compound 44) is a selective COX-1 ligand with a binding affinity (Kd or Ki value) of 22 nM for rhesus monkey COX-1 and 43 nM for human COX-1. It inhibits the binding of [3H]PS13 to human COX-1. When labeled with either 11C or 18F, COX-1ligand 1 can be utilized for COX-1 imaging and psychiatric disorder research.