Acalabrutinib maleate
Acalabrutinib maleate is an orally active, irreversible, highly selective second-generation BTK inhibitor. It forms a covalent bond with the Cys481 residue in the ATP-binding pocket of BTK. This compound demonstrates potent targeting effects and activity in a murine model of chronic lymphocytic leukemia (CLL) and is used in CLL research. Acalabrutinib maleate acts as a click chemistry reagent, containing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
Product Specifications
CAS Number
2242394-65-4
Smiles
C (=C\C (O) =O) \C (O) =O.C (C#CC) (=O) N1[C@H] (C=2N3C (=C (N2) C4=CC=C (C (NC5=CC=CC=N5) =O) C=C4) C (N) =NC=C3) CCC1
Molecular Formula
C30H27N7O6
Molecular Weight
581.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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