CZL-077
CZL-077 is a potent, highly selective, and orally active p300/CBP bromodomain (BRD) inhibitor, with p300 IC50 at 0.034 μM and CBP IC50 at 0.052 μM, demonstrating strong selectivity for the BRD of BET proteins (BRD2/3/4) . This compound effectively inhibits the growth of OPM-2 and 22RV1 cells, with IC50 values of 0.024 μM and 5.6 μM, respectively. In xenograft mouse models of OPM-2 and 22RV1, CZL-077 exhibits anti-tumor activity. CZL-077 is applicable for research in multiple myeloma and prostate cancer.
Product Specifications
CAS Number
3032444-06-4
Smiles
O=C1N ([C@H] (C=2N (C=3C (N2) =CC (=CC3) C=4C (C) =NOC4C) [C@H]5CC6=C (CC5) N=C (C) S6) C[C@@H]1F) C7=CC (F) =C (F) C=C7
Molecular Formula
C30H26F3N5O2S
Molecular Weight
577.63
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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