Razuprotafib sodium
Razuprotafib (AKB-9778) sodium is a potent and selective inhibitor of VE-PTP (HPTPη) catalytic activity, with an IC50 of 17 pM. It promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib sodium also inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Additionally, apart from HPTPη (IC50 of 36 pM) and HPTPγ (100 pM), it has good selectivity for VE-PTP.
Product Specifications
CAS Number
1809275-69-1
Smiles
[C@@H] (CC1=CC=C (NS (=O) (=O) O) C=C1) (NC ([C@H] (CC2=CC=CC=C2) NC (OC) =O) =O) C=3N=C (SC3) C4=CC=CS4.[Na]
Molecular Formula
C26H27N4NaO6S3
Molecular Weight
610.69
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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