XDS-23

XDS-23 is a selective biofilm inhibitor with an IC50 value of 1.26 μM against Pseudomonas aeruginosa. It exhibits dual inhibitory effects on the LasI/LasR system and the Pseudomonas Quinolone Signal system, suppressing key virulence factors such as elastase, pyocyanin, and extracellular polysaccharides. In both in vitro and in vivo models, XDS-23 demonstrates synergistic antibacterial activity, enhancing the efficacy of various antibiotics with good safety profile. XDS-23 is applicable for research related to treating biofilm-mediated resistant Pseudomonas aeruginosa infections.