AF03

AF03 is a larvicide targeting the larvae of Aedes aegypti mosquitoes, with an LC50 value of 41.6 μg/mL. It binds stably to the mosquito's sterol carrier protein-2 (AeSCP-2), disrupting lipid metabolism in the larvae. AF03 also increases acetylcholinesterase (AChE) activity in the zebrafish brain, slightly enhances catalase (CAT) activity in the liver and heart, and boosts superoxide dismutase (SOD) activity in the brain. It can be applied in research on arboviral infections such as dengue fever.