H36-E4
H36-E4 is an inhibitor of the E3 ubiquitin ligase 27 containing WW domains (WWP2), with a KD value of 6.25 μM. In a unilateral renal ischemia-reperfusion (UIR) mouse model, H36-E4 suppresses WWP2 expression, restores levels of succinate dehydrogenase complex subunit C (SDHC), and slows the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) . This compound is useful for research on the progression of AKI to CKD.
Product Specifications
CAS Number
688310-17-0
Smiles
O=C (N) C1CCN (C2=C (N=CN2C) N (=O) =O) CC1
Molecular Formula
C10H15N5O3
Molecular Weight
253.26
Storage Conditions
-20°C
Notes
For research use only.
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