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H36-E4

H36-E4 is an inhibitor of the E3 ubiquitin ligase 27 containing WW domains (WWP2), with a KD value of 6.25 μM. In a unilateral renal ischemia-reperfusion (UIR) mouse model, H36-E4 suppresses WWP2 expression, restores levels of succinate dehydrogenase complex subunit C (SDHC), and slows the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) . This compound is useful for research on the progression of AKI to CKD.

Product Specifications

CAS Number

688310-17-0

Smiles

O=C (N) C1CCN (C2=C (N=CN2C) N (=O) =O) CC1

Molecular Formula

C10H15N5O3

Molecular Weight

253.26

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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RAPGEF4 (Rap Guanine Nucleotide Exchange Factor 4, cAMP-regulated Guanine Nucleotide Exchange Factor II, cAMP-GEFII, CGEF2, Exchange Factor Directly Activated by cAMP 2, Exchange Protein Directly Activated by cAMP 2, EPAC 2, EPAC2, Nbla00496)
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